The effects of low doses of delta-9 tetrahydrocannabinol on reinforcement processing in the risky decision-making of young healthy adults.

Journal article

Research suggests that risky decision-making is sensitive to neuromodulatory influences acting upon corticolimbic circuitry. However, while other evidence attests to effects of delta-9 tetrahydrocannabinol (THC) on the activity of reward pathways, relatively little is known about the possible involvement of cannabinoid activity in risky choice. In this experiment, we examined the effects of a single sublingual 5 mg dose of THC on a test of risky decision-making (requiring choices between simu...

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Authors: Rogers, R; Wakeley, J; Robson, P; Bhagwagar, Z; Makela, P

• Publication status: Published
• Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
• Volume: 32
• Issue: 2
• Pages: 417-428
• Publication date: 2007-02-01
• DOI: 10.1038/sj.npp.1301175
• EISSN: 1740-634X
• ISSN: 0893-133X
• Language: English
• Keywords: Dose-Response Relationship, Drug; Tetrahydrocannabinol; Double-Blind Method; Neuropsychological Tests; Decision Making; Risk-Taking; Reinforcement (Psychology); Psychotropic Drugs; Brain; Humans; Attention; Reaction Time; Catecholamines; Adult; Female; Neural Pathways; Cognition; Placebos; Cognition Disorders; Cross-Over Studies; Age Factors; Male; Receptor, Cannabinoid, CB1