Impact of NOTCH1/FBXW7 mutations on outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on the MRC UKALL 2003 trial.

Journal article

Activating mutations in the NOTCH1 pathway are frequent in pediatric T-cell acute lymphoblastic leukemia (T-ALL) but their role in refining risk stratification is unclear. We screened 162 pediatric T-ALL patients treated on the MRC UKALL2003 trial for NOTCH1/FBXW7 gene mutations and related genotype to response to therapy and long-term outcome. Overall, 35% were wild-type (WT) for both genes (NOTCH1(WT)FBXW7(WT)), 38% single NOTCH1 mutant (NOTCH1(Single)FBXW7(WT)), 3% just FBXW7 mutant (NOTCH...

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Authors: Jenkinson, S; Koo, K; Mansour, MR; Goulden, N; Vora, A

• Publication status: Published
• Journal: Leukemia
• Volume: 27
• Issue: 1
• Pages: 41-47
• Publication date: 2013-01-01
• DOI: 10.1038/leu.2012.176
• EISSN: 1476-5551
• ISSN: 0887-6924
• Language: English
• Keywords: Cell Cycle Proteins; Survival Rate; Female; Ubiquitin-Protein Ligases; Cohort Studies; Adult; Daunorubicin; Genotype; F-Box Proteins; Male; Child, Preschool; Child; Infant; Young Adult; Dexamethasone; Humans; Adolescent; Vincristine; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Mutation; Prognosis; Receptor, Notch1; Polymerase Chain Reaction; Remission Induction; Antineoplastic Combined Chemotherapy Protocols; DNA, Neoplasm; Asparaginase