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Modeling chemotaxis reveals the role of reversed phosphotransfer and a Bi-functional kinase-phosphatase

Abstract:

Understanding how multiple signals are integrated in living cells to produce a balanced response is a major challenge in biology. Two-component signal transduction pathways, such as bacterial chemotaxis, comprise histidine protein kinases (HPKs) and response regulators (RRs). These are used to sense and respond to changes in the environment. Rhodobacter sphaeroides has a complex chemosensory network with two signaling clusters, each containing a HPK, CheA. Here we demonstrate, using a mathema...

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Publisher copy:
10.1371/journal.pcbi.1000896

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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
PLoS Computational Biology
Volume:
6
Issue:
8
Publication date:
2010-08-01
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
Source identifiers:
93389
Language:
English
UUID:
uuid:c4f6e3ab-dd90-4b19-80f7-8c28cdbfa53f
Local pid:
pubs:93389
Deposit date:
2012-12-19

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