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Integrating models to quantify environment mediated drug resistance

Abstract:

Drug resistance is the single most important driver of cancer treatment failure for modern targeted therapies, and the dialogue between tumor and stroma has been shown to modulate the response to molecularly targeted therapies through proliferative and survival signaling. In this work, we investigate interactions between a growing tumor and its surrounding stroma and their role in facilitating the emergence of drug resistance. We used mathematical modeling as a theoretical framework to bridge...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1158/0008-5472.CAN-17-0835

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Department:
St Johns College
Role:
Author
Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Research Journal website
Volume:
77
Issue:
19
Pages:
5409-5418
Publication date:
2017-07-28
Acceptance date:
2017-07-19
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Pubs id:
pubs:709371
URN:
uri:c4f4152d-5fbf-4c0d-a431-16e46c4b0850
UUID:
uuid:c4f4152d-5fbf-4c0d-a431-16e46c4b0850
Local pid:
pubs:709371

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