- Abstract:
-
Drug resistance is the single most important driver of cancer treatment failure for modern targeted therapies, and the dialogue between tumor and stroma has been shown to modulate the response to molecularly targeted therapies through proliferative and survival signaling. In this work, we investigate interactions between a growing tumor and its surrounding stroma and their role in facilitating the emergence of drug resistance. We used mathematical modeling as a theoretical framework to bridge...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 184.6KB)
-
(pdf, 1.5MB)
-
(pdf, 1.9MB)
-
- Publisher copy:
- 10.1158/0008-5472.CAN-17-0835
-
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- Publisher:
- American Association for Cancer Research Publisher's website
- Journal:
- Cancer Research Journal website
- Volume:
- 77
- Issue:
- 19
- Pages:
- 5409-5418
- Publication date:
- 2017-07-28
- Acceptance date:
- 2017-07-19
- DOI:
- EISSN:
-
1538-7445
- ISSN:
-
0008-5472
- Pubs id:
-
pubs:709371
- URN:
-
uri:c4f4152d-5fbf-4c0d-a431-16e46c4b0850
- UUID:
-
uuid:c4f4152d-5fbf-4c0d-a431-16e46c4b0850
- Local pid:
- pubs:709371
- Copyright holder:
- ©2017, American Association for Cancer Research.
- Copyright date:
- 2017
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from American Association for Cancer Research at: 10.1158/0008-5472.CAN-17-0835
Journal article
Integrating models to quantify environment mediated drug resistance
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