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The scaffold protein Ajuba suppresses CdGAP activity in epithelia to maintain stable cell-cell contacts

Abstract:

Levels of active Rac1 at epithelial junctions are partially modulated via interaction with Ajuba, an actin binding and scaffolding protein. Here we demonstrate that Ajuba interacts with the Cdc42 GTPase activating protein CdGAP, a GAP for Rac1 and Cdc42, at cell-cell contacts. CdGAP recruitment to junctions does not require Ajuba; rather Ajuba seems to control CdGAP residence at sites of cell-cell adhesion. CdGAP expression potently perturbs junctions and Ajuba binding inhibits CdGAP activity...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-017-09024-4

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Funding agency for:
Bruche, S
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Funding agency for:
Ouadda, ABD
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Funding agency for:
Garcia-Cattaneo, A
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Issue:
9249
Pages:
1-14
Publication date:
2017-08-23
Acceptance date:
2017-07-20
DOI:
ISSN:
2045-2322
Pubs id:
pubs:723954
URN:
uri:c4e9d5b1-a455-4a28-9fa7-5ea5d571b6e9
UUID:
uuid:c4e9d5b1-a455-4a28-9fa7-5ea5d571b6e9
Local pid:
pubs:723954

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