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A potential biomarker of kidney damage identified by proteomics: preliminary findings.

Abstract:

4-Aminophenol (4-AP) and D-serine are established rodent nephrotoxins that selectively damage renal proximal tubules. In an attempt to understand the mechanism of action of these toxicants in greater detail, a high throughput proteomics approach was used to profile protein changes in the plasma of animals treated with these compounds. Male Fischer 344 and Alderley Park rats were treated with increasing doses of 4-AP or D-serine and plasma samples were collected over time. Control groups recei...

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Publication status:
Published

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Authors


Bandara, LR More by this author
Kennedy, S More by this author
Journal:
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
Volume:
8
Issue:
3-4
Pages:
272-286
Publication date:
2003
DOI:
EISSN:
1366-5804
ISSN:
1354-750X
URN:
uuid:c4e66ca0-e7f2-42cb-a5b3-1e422dbf4458
Source identifiers:
321920
Local pid:
pubs:321920

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