- Abstract:
-
4-Aminophenol (4-AP) and D-serine are established rodent nephrotoxins that selectively damage renal proximal tubules. In an attempt to understand the mechanism of action of these toxicants in greater detail, a high throughput proteomics approach was used to profile protein changes in the plasma of animals treated with these compounds. Male Fischer 344 and Alderley Park rats were treated with increasing doses of 4-AP or D-serine and plasma samples were collected over time. Control groups recei...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1080/13547500412331332977
-
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- Journal:
- Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
- Volume:
- 8
- Issue:
- 3-4
- Pages:
- 272-286
- Publication date:
- 2003
- DOI:
- EISSN:
-
1366-5804
- ISSN:
-
1354-750X
- URN:
-
uuid:c4e66ca0-e7f2-42cb-a5b3-1e422dbf4458
- Source identifiers:
-
321920
- Local pid:
- pubs:321920
- Copyright date:
- 2003
Journal article
A potential biomarker of kidney damage identified by proteomics: preliminary findings.
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