Study rationale and design of ADVANCE: action in diabetes and vascular disease--preterax and diamicron MR controlled evaluation.

Journal article

AIMS/HYPOTHESIS: Patients with Type II (non-insulin-dependent) diabetes mellitus are at increased risk of macrovascular and microvascular disease, both of which are reduced by controlling raised blood pressure in hypertensive patients. Intensive glycaemic control has also been shown to reduce microvascular disease but the effects on macrovascular disease remain uncertain. This study will examine the hypotheses that lowering blood pressure with an ACE inhibitor-diuretic combination and intens...

Expand abstract

Authors: ADVANCE Management Committee

• Journal: Diabetologia
• Volume: 44
• Issue: 9
• Pages: 1118-1120
• Publication date: 2001-09-01
• DOI: 10.1007/s001250100612
• EISSN: 1432-0428
• ISSN: 0012-186X
• Language: English
• Keywords: Middle Aged; Multicenter Studies as Topic; Diuretics; Placebos; Gliclazide; Indapamide; Humans; ADVANCE Management Committee; Diabetes Mellitus, Type 2; Aged; Randomized Controlled Trials as Topic; Angiotensin-Converting Enzyme Inhibitors; Perindopril; Hypertension; Clinical Protocols; Hypoglycemic Agents; Diabetic Angiopathies; Sulfonylurea Compounds