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Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Abstract:

Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms-many related to the structure or function of red blood cells-and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress.We did a case-control study in Kilifi County, Kenya. We recruited as cases children presenting with severe malaria to the high-dependency ward o...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/S2352-3026(18)30107-8

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
Macharia, AW More by this author
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Funding agency for:
Kwiatkowski, DP
Publisher:
Elsevier Publisher's website
Journal:
Lancet Haematology Journal website
Volume:
5
Issue:
8
Pages:
e333-e345
Publication date:
2018-07-20
Acceptance date:
2018-06-28
DOI:
EISSN:
2352-3026
Pubs id:
pubs:891367
URN:
uri:c4d6ee94-f679-4af1-986d-6ab39c7697f3
UUID:
uuid:c4d6ee94-f679-4af1-986d-6ab39c7697f3
Local pid:
pubs:891367
Language:
English
Keywords:

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