Comparative analysis of the Plasmodium falciparum histidine-rich proteins HRP-I, HRP-II and HRP-III in malaria parasites of diverse origin.

Journal article

Plasmodium falciparum-infected erythrocytes (IRBC) synthesize 3 histidine-rich proteins: HRP-I or the knob-associated HRP, HRP-II and HRP-III or SHARP. In order to distinguish these proteins immunochemically we prepared monoclonal antibodies which react with HRP-I, HRP-II and HRP-III, and rabbit antisera against synthetic peptides derived from the HRP-II and HRP-III sequences. A comparative analysis of diverse P. falciparum parasites was made using these antibodies and immunoprecipitation or ...

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Authors: Rock, E; Marsh, K; Saul, A; Wellems, T; Taylor, D

• Publication status: Published
• Journal: Parasitology
• Volume: 95 ( Pt 2)
• Issue: 02
• Pages: 209-227
• Publication date: 1987-10-01
• DOI: 10.1017/s0031182000057681
• EISSN: 1469-8161
• ISSN: 0031-1820
• Language: English
• Keywords: Plasmodium falciparum; Female; Immune Sera; Antibodies, Monoclonal; Humans; Immunoassay; Glycoproteins; Proteins; Fluorescent Antibody Technique; Electrophoresis, Polyacrylamide Gel; Animals; Adult; Plasmodium malariae; Erythrocytes