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HLA-E is expressed on trophoblast and interacts with CD94/NKG2 receptors on decidual NK cells.

Abstract:

Non-classical MHC class I molecule HLA-E is the ligand for CD94/NKG2 NK cell receptors. Surface expression of HLA-E requires binding of specific HLA class I leader sequences. The uterine mucosa in early pregnancy (decidua) is infiltrated by large numbers of NK cells, which are closely associated with placental trophoblast cells. In this study we demonstrate that trophoblast cells express HLA-E on their cell surface in addition to the previously reported expression of HLA-G and HLA-C. Furtherm...

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Publication status:
Published

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Journal:
European journal of immunology
Volume:
30
Issue:
6
Pages:
1623-1631
Publication date:
2000-06-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Source identifiers:
37482

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