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Cyclic AMP potentiates glucose-induced insulin release from mouse pancreatic islets without increasing cytosolic free Ca2+.

Abstract:

The effects of various stimulants of insulin release on cytosolic free Ca2+, [Ca2+]i, in dispersed and cultured pancreatic beta-cells from ob/ob-mice were studied using the indicator quin-2, which in itself has only slight effects on the glucose-induced insulin release and the metabolism of the sugar. The resting [Ca2+]i was 158 +/- 7 nM. After increasing glucose to 20 mM there was a lag-period of 1-2 min before [Ca2+]i gradually rose, reaching a new plateau 60% higher after 5-6 min. Increasi...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Journal:
Acta physiologica Scandinavica
Volume:
125
Issue:
4
Pages:
639-647
Publication date:
1985-12-05
DOI:
EISSN:
1365-201X
ISSN:
0001-6772
URN:
uuid:c4cea97c-e7e6-4ff9-9496-cab36dcea6ba
Source identifiers:
26972
Local pid:
pubs:26972

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