Journal article
HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.
- Abstract:
-
The protein HLA-E is a non-classical major histocompatibility complex (MHC) molecule of limited sequence variability. Its expression on the cell surface is regulated by the binding of peptides derived from the signal sequence of some other MHC class I molecules. Here we report the identification of ligands for HLA-E. We constructed tetramers in which recombinant HLA-E and beta2-microglobulin were refolded with an MHC leader-sequence peptide, biotinylated, and conjugated to phycoerythrin-label...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/35869
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Authors
Bibliographic Details
- Journal:
- Nature
- Volume:
- 391
- Issue:
- 6669
- Pages:
- 795-799
- Publication date:
- 1998-02-01
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- Source identifiers:
-
20353
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:20353
- UUID:
-
uuid:c4b641b9-0ddc-44cf-8736-de5b164152a5
- Local pid:
- pubs:20353
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1998
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