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HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.

Abstract:

The protein HLA-E is a non-classical major histocompatibility complex (MHC) molecule of limited sequence variability. Its expression on the cell surface is regulated by the binding of peptides derived from the signal sequence of some other MHC class I molecules. Here we report the identification of ligands for HLA-E. We constructed tetramers in which recombinant HLA-E and beta2-microglobulin were refolded with an MHC leader-sequence peptide, biotinylated, and conjugated to phycoerythrin-label...

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Publication status:
Published

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Publisher copy:
10.1038/35869

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Role:
Author
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Journal:
Nature
Volume:
391
Issue:
6669
Pages:
795-799
Publication date:
1998-02-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:c4b641b9-0ddc-44cf-8736-de5b164152a5
Source identifiers:
20353
Local pid:
pubs:20353

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