Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery.
BACKGROUND: The activation of T lymphocytes by specific antigen is accompanied by the formation of a specialized signaling region termed the immunological synapse, characterized by the clustering and segregation of surface molecules and, in particular, by T cell receptor (TCR) clustering. METHODOLOGY/PRINCIPAL FINDINGS: To better understand TCR motion during cellular activation, we used confocal microscopy and photo-bleaching recovery techniques to investigate the lateral mobility of TCR on ...Expand abstract
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- Peer reviewed
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- Copyright holder:
- Dushek et al.
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- Copyright 2008 Dushek et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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