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Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery.

Abstract:

BACKGROUND: The activation of T lymphocytes by specific antigen is accompanied by the formation of a specialized signaling region termed the immunological synapse, characterized by the clustering and segregation of surface molecules and, in particular, by T cell receptor (TCR) clustering. METHODOLOGY/PRINCIPAL FINDINGS: To better understand TCR motion during cellular activation, we used confocal microscopy and photo-bleaching recovery techniques to investigate the lateral mobility of TCR on ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0003913

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Mueller, S More by this author
Soubies, S More by this author
Caramalho, I More by this author
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Ligue contre le Cancer More from this funder
National Science and Engineering Research Council More from this funder
Mathematics in Technology and Complex Systems National Centre of Excellence, Canada More from this funder
Fundacao para Ciencia e a Tecnologia, Portugal More from this funder
France-Canada Research Fund More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
3
Issue:
12
Pages:
Article: e3913
Publication date:
2008
DOI:
EISSN:
1932-6203
URN:
uuid:c4b1b6ff-b5f6-43fd-94ce-9cf8ea0999d0
Source identifiers:
237231
Local pid:
pubs:237231

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