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A physics-based model explains the prion-like features of neurodegeneration in Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis

Abstract:

Prion disease is characterized by a chain reaction in which infectious misfolded proteins force native proteins into a similar pathogenic structure. Recent studies have reinforced the hypothesis that the prion paradigm–the templated growth and spreading of misfolded proteins–could help explain a variety of neurodegenerative disorders. However, our current understanding of prion-like growth and spreading is rather empirical. Here we show that a physics-based reaction-diffusion model can explai...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jmps.2018.10.013

Authors


Weickenmeier, J More by this author
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Oxford college:
St Catherines College
ORCID:
0000-0002-6436-8483
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Grant:
seed grant ’Molecular Mechanisms of Chronic Traumatic Encephalopathy’
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Grant:
CMMI 1727268 ’Understanding Neurodegeneration across the Scales’
Publisher:
Elsevier Publisher's website
Journal:
Journal of the Mechanics and Physics of Solids Journal website
Volume:
124
Pages:
264-281
Publication date:
2018-10-15
Acceptance date:
2018-10-15
DOI:
ISSN:
0022-5096
Pubs id:
pubs:927351
URN:
uri:c4afd44d-648a-492f-8faa-4c7f1007505e
UUID:
uuid:c4afd44d-648a-492f-8faa-4c7f1007505e
Local pid:
pubs:927351

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