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NalP-mediated proteolytic release of lactoferrin-binding protein B from the meningococcal cell surface.

Abstract:

Bacteria have developed several mechanisms for iron uptake during colonization of mammalian hosts, where the availability of free iron is limiting for growth. Neisseria meningitidis expresses under iron-limiting conditions a receptor complex consisting of the lactoferrin-binding proteins A (LbpA) and LbpB to acquire iron from lactoferrin, which is abundantly present on the mucosal surfaces of the human nasopharynx. LbpA is an integral outer membrane-embedded iron transporter, whereas LbpB is ...

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Publisher copy:
10.1128/iai.01193-09

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Infection and immunity
Volume:
78
Issue:
7
Pages:
3083-3089
Publication date:
2010-07-05
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:c4ae3443-6ea7-479f-9e4a-8bfa87cb4854
Source identifiers:
252377
Local pid:
pubs:252377

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