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Allograft rejection mediated by memory T cells is resistant to regulation.

Abstract:

Alloreactive memory T cells may be refractory to many of the tolerance-inducing strategies that are effective against naive T cells and thus present a significant barrier to long-term allograft survival. Because CD4(+)CD25(+) regulatory T cells (Tregs) are critical elements of many approaches to successful induction/maintenance of transplantation tolerance, we used MHC class I and II alloreactive TCR-transgenic models to explore the ability of antigen-specific Tregs to control antigen-specifi...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0704397104

Authors


Carvalho-Gaspar, M More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
104
Issue:
50
Pages:
19954-19959
Publication date:
2007-12-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:c4a5ae4e-336c-414e-9d4e-889babc804a6
Source identifiers:
136011
Local pid:
pubs:136011

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