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Harnessing dendritic cells for the induction of transplantation tolerance.

Abstract:

PURPOSE OF REVIEW: The unique properties of dendritic cells (DC) lend themselves to the modulation of antigen-specific immune responses, including allograft rejection. Central to their modulatory function is the capacity of DC to polarize naïve T cells towards a regulatory phenotype and to expand existing regulatory T cells (Treg). This review draws on current understanding of the interaction between these critical cell types to evaluate prospects for the use of DC as a therapeutic regimen. ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Current opinion in organ transplantation
Volume:
14
Issue:
4
Pages:
344-350
Publication date:
2009-08-05
DOI:
EISSN:
1531-7013
ISSN:
1087-2418
URN:
uuid:c49ae95b-50e1-4a31-ac20-47025bcb8c52
Source identifiers:
9799
Local pid:
pubs:9799

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