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Polymorphisms in inflammation pathway genes and endometrial cancer risk.

Abstract:

BACKGROUND: Experimental and epidemiologic evidence have suggested that chronic inflammation may play a critical role in endometrial carcinogenesis. METHODS: To investigate this hypothesis, a two-stage study was carried out to evaluate single-nucleotide polymorphisms (SNP) in inflammatory pathway genes in association with endometrial cancer risk. In stage I, 64 candidate pathway genes were identified and 4,542 directly genotyped or imputed SNPs were analyzed among 832 endometrial cancer cases...

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Publication status:
Published

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Authors


Delahanty, RJ More by this author
Spurdle, A More by this author
Beeghly-Fadiel, A More by this author
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Journal:
Cancer epidemiology, biomarkers and prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Volume:
22
Issue:
2
Pages:
216-223
Publication date:
2013-02-05
DOI:
EISSN:
1538-7755
ISSN:
1055-9965
URN:
uuid:c4995e25-d2c9-4ed2-b29d-b0e520e9bd79
Source identifiers:
384731
Local pid:
pubs:384731

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