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Blinding in trials of interventional procedures is possible and worthwhile

Abstract:

In this paper, we have used evidence from our earlier review of surgical randomised controlled trials with a placebo arm to show that blinding in trials of interventional procedures is feasible, and that many creative methods can be used to make the active and the placebo procedure as similar as possible. We give examples of ingenious strategies used to simulate the active procedure and make the placebo control indistinguishable from the active treatment. We discuss why it is important to bli...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.12688/f1000research.12528.2

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
National Institute for Health Research More from this funder
Publisher:
F1000Research Publisher's website
Journal:
F1000 Research Journal website
Volume:
6
Issue:
1663
Pages:
1-16
Publication date:
2018-01-30
Acceptance date:
2018-01-30
DOI:
ISSN:
2046-1402
Source identifiers:
726025
Pubs id:
pubs:726025
UUID:
uuid:c48f247d-77a3-429e-a6df-24be069502be
Local pid:
pubs:726025
Deposit date:
2017-09-08

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