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Journal article

Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels.

Abstract:

1. We examined the effect of the sulphonylurea glimepiride on three types of recombinant ATP-sensitive potassium (K(ATP)) channels. 2. K(ATP) channels share a common pore-forming subunit, Kir6.2, which associates with different sulphonylurea receptor isoforms (SUR1 in beta-cells, SUR2A in heart and SUR2B in smooth muscle). 3. Kir6.2 was coexpressed with SUR1, SUR2A or SUR2B in Xenopus oocytes and macroscopic K(ATP) currents were recorded from giant inside-out membrane patches. Glimepiride was...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjp.0704062

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
British journal of pharmacology
Volume:
133
Issue:
1
Pages:
193-199
Publication date:
2001-05-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:c48f0814-63b2-4234-975e-2f3628c6cf48
Source identifiers:
114494
Local pid:
pubs:114494

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