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A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses.

Abstract:

Virus like particles (VLPs) are known to induce potent B cell responses in the absence of adjuvants. Moreover, epitope-specific antibody responses may be induced by VLPs that contain peptides inserted in their immunodominant regions. However, due to steric problems, the size of the peptides capable of being incorporated into VLPs while still permitting capsid assembly, is rather limited. While peptides genetically fused to either the N- or C-terminus of VLPs present fewer assembly problems, t...

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Publication status:
Published

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Authors


Jegerlehner, A More by this author
Lechner, F More by this author
Erdmann, I More by this author
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Journal:
Vaccine
Volume:
20
Issue:
25-26
Pages:
3104-3112
Publication date:
2002-08-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:c47a195f-172d-437a-ab38-4654d62100d5
Source identifiers:
469704
Local pid:
pubs:469704

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