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Journal article

Effects of NXY-059 in experimental stroke: an individual animal meta-analysis.

Abstract:

BACKGROUND AND PURPOSE: Disodium 2,4-disulphophenyl-N-tert-butylnitrone (NXY-059) was neuroprotective in experimental stroke models but ineffective in a large clinical trial. This first-ever individual animal meta-analysis was used to assess the preclinical studies. EXPERIMENTAL APPROACH: Studies were obtained from AstraZeneca and PubMed searches. Data for each animal were obtained from the lead author of each study and/or AstraZeneca. Published summary data were used if individual data were...

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Publication status:
Published

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Journal:
British journal of pharmacology
Volume:
157
Issue:
7
Pages:
1157-1171
Publication date:
2009-08-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:c4779e2d-0452-48a1-9df4-71f5eaf282e2
Source identifiers:
79250
Local pid:
pubs:79250

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