Effects of NXY-059 in experimental stroke: an individual animal meta-analysis.

Journal article

BACKGROUND AND PURPOSE: Disodium 2,4-disulphophenyl-N-tert-butylnitrone (NXY-059) was neuroprotective in experimental stroke models but ineffective in a large clinical trial. This first-ever individual animal meta-analysis was used to assess the preclinical studies. EXPERIMENTAL APPROACH: Studies were obtained from AstraZeneca and PubMed searches. Data for each animal were obtained from the lead author of each study and/or AstraZeneca. Published summary data were used if individual data were...

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Authors: Bath, P; Gray, L; Bath, A; Buchan, A; Miyata, T

• Publication status: Published
• Journal: British journal of pharmacology
• Volume: 157
• Issue: 7
• Pages: 1157-1171
• Publication date: 2009-08-01
• DOI: 10.1111/j.1476-5381.2009.00196.x
• EISSN: 1476-5381
• ISSN: 0007-1188
• Language: English
• Keywords: Callithrix; Disease Models, Animal; NXY-059 Efficacy Meta-analysis in Individual Animals with Stroke Investigators; Mice; Drug Evaluation, Preclinical; Random Allocation; Male; Animals; Female; Benzenesulfonates; Neuroprotective Agents; Rats; Stroke; Brain