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Nanographene oxide-based radioimmunoconstructs for in vivo targeting and SPECT imaging of HER2-positive tumors.

Abstract:

Nanographene oxide (NGO) is a novel nano-wall material that tracks to tumors in vivo, and which, as a consequence of its large surface area, has the capacity to carry a large payload. This study explores the use of anti-HER2 antibody (trastuzumab)-conjugated NGO, radiolabeled with (111)In-benzyl-diethylenetriaminepentaacetic acid (BnDTPA) via ππ-stacking, for functional imaging. In two HER2-overexpressing murine models of human breast cancer, high tumor-to-muscle ratio was achieved, resulting...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Materials
Role:
Author
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CR-UK/EPSRC/MRC/NIHR Oxford Cancer Imaging Centre More from this funder
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Cancer Research UK More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Biomaterials Journal website
Volume:
34
Issue:
4
Pages:
1146-1154
Publication date:
2013-01-05
DOI:
EISSN:
1878-5905
ISSN:
0142-9612
URN:
uuid:c46f0f25-8e08-4ee4-9ff2-d19ceefab613
Source identifiers:
363856
Local pid:
pubs:363856

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