Elevated levels of endothelial cell-derived microparticles following short-term withdrawal of continuous positive airway pressure in patients with obstructive sleep apnea: Data from a randomized controlled trial

Ayers, L; Ferry, B; Stradling, J; Stoewhas, A; Kohler, M

Journal article

Elevated levels of endothelial cell-derived microparticles following short-term withdrawal of continuous positive airway pressure in patients with obstructive sleep apnea: Data from a randomized controlled trial

Abstract:: Background: Obstructive sleep apnea has been associated with impaired endothelial function; however, the mechanisms underlying this association are not completely understood. Cell-derived microparticles may provide a link between obstructive sleep apnea and endothelial dysfunction. Objectives: This randomized controlled trial aimed to examine the effect of a 2-week withdrawal of continuous positive airway pressure (CPAP) therapy on levels of circulating microparticles. Methods: Forty-one obstructive sleep apnea patients established on CPAP treatment were randomized to either CPAP withdrawal (subtherapeutic CPAP) or continuing therapeutic CPAP, for 2 weeks. Polysomnography was performed and circulating levels of microparticles were analyzed by flow cytometry at baseline and 2 weeks. Results: CPAP withdrawal led to a recurrence of obstructive sleep apnea. Levels of CD62E+ endothelium-derived microparticles increased significantly in the CPAP withdrawal group compared to the continuing therapeutic CPAP group (median difference in change +32.4 per μl; 95% CI +7.3 to +64.1 per μl, p = 0.010). CPAP withdrawal was not associated with a statistically significant increase in granulocyte, leukocyte, and platelet-derived microparticles when compared with therapeutic CPAP. Conclusions: Short-term withdrawal of CPAP therapy leads to a significant increase in endothelium-derived microparticles, suggesting that microparticle formation may be causally linked to obstructive sleep apnea and may promote endothelial activation. Copyright © 2012 S. Karger AG, Basel.

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APA Style

Ayers, L., Ferry, B., Stradling, J., Stoewhas, A., & Kohler, M. (2013). Elevated levels of endothelial cell-derived microparticles following short-term withdrawal of continuous positive airway pressure in patients with obstructive sleep apnea: Data from a randomized controlled trial. Respiration, 85(6), 478–485.

MLA Style

Ayers, L., et al. “Elevated Levels of Endothelial Cell-Derived Microparticles Following Short-Term Withdrawal of Continuous Positive Airway Pressure in Patients with Obstructive Sleep Apnea: Data from a Randomized Controlled Trial.” Respiration, vol. 85, no. 6, 2013, pp. 478–85.

Chicago Style

Ayers, L, B Ferry, J Stradling, A Stoewhas, and M Kohler. 2013. “Elevated Levels of Endothelial Cell-Derived Microparticles Following Short-Term Withdrawal of Continuous Positive Airway Pressure in Patients with Obstructive Sleep Apnea: Data from a Randomized Controlled Trial.” Respiration 85 (6): 478–85.
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