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Molecular cytogenetic delineation of the critical deleted region in the 5q- syndrome.

Abstract:

The 5q- syndrome is a distinct type of myelodysplastic syndrome (MDS) characterised by refractory anaemia, morphological abnormalities of megakaryocytes, and del(5q) as the sole cytogenetic abnormality. In contrast to patients with therapy-related MDS with 5q deletions, 5q- syndrome patients have a favourable prognosis and a low rate of transformation to acute leukaemia. We have previously delineated a common deleted region of 5.6 Mb between the gene for fibroblast growth factor acidic (FGF1)...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Biomedical Research Centre
Oliver, FJ More by this author
Kostrzewa, M More by this author
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Journal:
Genes, chromosomes and cancer
Volume:
22
Issue:
3
Pages:
251-256
Publication date:
1998-07-05
DOI:
EISSN:
1098-2264
ISSN:
1045-2257
URN:
uuid:c45a049a-a824-40db-96da-18f09554df16
Source identifiers:
375305
Local pid:
pubs:375305

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