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Methods for meta-analysis of pharmacodynamic dose-response data with application to multi-arm studies of alogliptin

Abstract:

Standard methods for meta-analysis of dose-response data in epidemiology assume a model with a single scalar parameter, such as log-linear relationships between exposure and outcome; such models are implicitly unbounded. In contrast, in pharmacology, multi-parameter models, such as the widely used Emax model, are used to describe relationships that are bounded above and below. We propose methods for estimating the parameters of a dose-response model by meta-analysis of summary data from the r...

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Publication status:
Accepted
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Stats
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Stats
van Valkenhoef, G More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Stats
Publisher:
SAGE Publisher's website
Journal:
Statistical Methods in Medical Research Journal website
Publication date:
2016
EISSN:
1477-0334
ISSN:
0962-2802
URN:
uuid:c451b547-076c-4778-9306-bc279a85d2ed
Source identifiers:
601733
Local pid:
pubs:601733

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