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Thesis

Structure and function studies of K2P channels

Abstract:

Members of the two-pore potassium-selective (K2P) ion channel superfamily control cell excitability by contributing to the resting membrane potential. Through this, K2P channels are involved in a variety of physiological processes and dysfunction of these channels has been linked to diseases such as epilepsy, depression and migraine. The aim of this study was to develop a greater understanding of how K2P channels, in particular TREK-1, are gated.

In the initial stage of this study w...

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Division:
MPLS
Department:
Physics
Subgroup:
Condensed Matter Physics
Oxford college:
Linacre College
Role:
Author

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Division:
MPLS
Department:
Physics
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:c449026b-a8a4-4501-9b75-386658a2035e
Local pid:
ora:7135
Language:
English
Keywords:
Subjects:

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