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A matched set of rat/mouse chimeric antibodies. Identification and biological properties of rat H chain constant regions mu, gamma 1, gamma 2a, gamma 2b, gamma 2c, epsilon, and alpha.

Abstract:

Rat C regions mu, gamma 1, gamma 2a, gamma 2b, gamma 2c, epsilon, and alpha have been characterized by means of chimeric antibody technology. A set of rat/mouse Ag-specific (anti-4-hydroxy-3-nitrophenacetyl) antibodies was constructed that differ only in the H chain constant region but carry identical V region and L chain, both of which are of mouse origin. All rat constant regions could be expressed and m.w. were as expected from the protein sequence. A slight variation in mobility within th...

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
142
Issue:
9
Pages:
3145-3150
Publication date:
1989-05-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:c4445f8e-dd4f-4796-aca8-b2dd920f2d5f
Source identifiers:
2805
Local pid:
pubs:2805

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