Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).

Journal article

Twin studies suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort Consortium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3 alpha-androstanediol-glucuronide (N = 4767) and 17beta-estradiol (N = 2014) in Caucasian men. rs1799941 in SHBG is highly significantly associated with circula...

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Authors: Ahn, J; Schumacher, F; Berndt, S; Pfeiffer, R; Albanes, D

• Publication status: Published
• Journal: Human molecular genetics
• Volume: 18
• Issue: 19
• Pages: 3749-3757
• Publication date: 2009-10-01
• DOI: 10.1093/hmg/ddp302
• EISSN: 1460-2083
• ISSN: 0964-6906
• Language: English
• Keywords: Quantitative Trait Loci; Adult; European Continental Ancestry Group; Male; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Gonadal Steroid Hormones; Sex Hormone-Binding Globulin; Cohort Studies; Aged, 80 and over; Middle Aged; Estrogen Receptor alpha; Case-Control Studies; Prostatic Neoplasms; Humans; Aged