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NO-cGMP pathway increases the hyperpolarisation-activated current, I(f), and heart rate during adrenergic stimulation.

Abstract:

OBJECTIVES: The role of the nitric oxide (NO)-cGMP pathway in the autonomic modulation of cardiac pacemaking is controversial and may involve an interplay between the L-type calcium current, I(CaL), and the hyperpolarisation activated current, I(f). We tested the hypothesis that following adrenergic stimulation, the NO-cGMP pathway stimulates phosphodiesterase 2 (PDE2) to reduce cAMP dependent stimulation of I(f) and heart rate (HR). METHODS: In the presence of norepinephrine (NE, 1 microM), ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Role:
Author
Journal:
Cardiovascular research
Volume:
52
Issue:
3
Pages:
446-453
Publication date:
2001-12-05
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
URN:
uuid:c43a88b6-8af1-45e5-88ae-657ed9853594
Source identifiers:
104937
Local pid:
pubs:104937

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