NO-cGMP pathway increases the hyperpolarisation-activated current, I(f), and heart rate during adrenergic stimulation.

Journal article

OBJECTIVES: The role of the nitric oxide (NO)-cGMP pathway in the autonomic modulation of cardiac pacemaking is controversial and may involve an interplay between the L-type calcium current, I(CaL), and the hyperpolarisation activated current, I(f). We tested the hypothesis that following adrenergic stimulation, the NO-cGMP pathway stimulates phosphodiesterase 2 (PDE2) to reduce cAMP dependent stimulation of I(f) and heart rate (HR). METHODS: In the presence of norepinephrine (NE, 1 microM), ...

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Authors: Herring, N; Rigg, L; Terrar, D; Paterson, D

• Publication status: Published
• Journal: Cardiovascular research
• Volume: 52
• Issue: 3
• Pages: 446-453
• Publication date: 2001-12-01
• DOI: 10.1016/s0008-6363(01)00425-4
• EISSN: 1755-3245
• ISSN: 0008-6363
• Language: English
• Keywords: Animals; Cyclic Nucleotide Phosphodiesterases, Type 2; Reverse Transcriptase Polymerase Chain Reaction; 3',5'-Cyclic-AMP Phosphodiesterases; Norepinephrine; Nitroprusside; Guinea Pigs; Ion Channels; Pyrimidines; Patch-Clamp Techniques; Phosphoric Diester Hydrolases; Chlorides; Calcium Channel Blockers; Sinoatrial Node; Adenine; Stimulation, Chemical; Phosphodiesterase Inhibitors; Heart Rate; Nitric Oxide; Cyclic GMP; Guanylate Cyclase; Cesium; 8-Bromo Cyclic Adenosine Monophosphate; Female; Nitric Oxide Donors; RNA, Messenger