Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2.

Journal article

Mitotic kinases of the Polo and Aurora families are key regulators of chromosome segregation and cytokinesis. Here, we have investigated the role of MKlp1 and MKlp2, two vertebrate mitotic kinesins essential for cytokinesis, in the spatial regulation of the Aurora B kinase. Previously, we have demonstrated that MKlp2 recruits Polo-like kinase 1 (Plk1) to the central spindle in anaphase. We now find that in MKlp2 but not MKlp1-depleted cells the Aurora B-INCENP complex remains at the centromer...

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Authors: Gruneberg, U; Neef, R; Honda, R; Nigg, E; Barr, F

• Publication status: Published
• Journal: Journal of cell biology
• Volume: 166
• Issue: 2
• Pages: 167-172
• Publication date: 2004-07-01
• DOI: 10.1083/jcb.200403084
• EISSN: 1540-8140
• ISSN: 0021-9525
• Language: English
• Keywords: Protein Transport; Proto-Oncogene Proteins; Metaphase; Phosphoric Monoester Hydrolases; Cell Cycle Proteins; Humans; Mitotic Spindle Apparatus; Macromolecular Substances; Zebrafish Proteins; Protein Kinases; Chromosomal Proteins, Non-Histone; Microtubule-Associated Proteins; Anaphase; Protein-Serine-Threonine Kinases; Hela Cells; Phosphorylation; Centromere; Kinesin