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Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2.

Abstract:

Mitotic kinases of the Polo and Aurora families are key regulators of chromosome segregation and cytokinesis. Here, we have investigated the role of MKlp1 and MKlp2, two vertebrate mitotic kinesins essential for cytokinesis, in the spatial regulation of the Aurora B kinase. Previously, we have demonstrated that MKlp2 recruits Polo-like kinase 1 (Plk1) to the central spindle in anaphase. We now find that in MKlp2 but not MKlp1-depleted cells the Aurora B-INCENP complex remains at the centromer...

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Publication status:
Published

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Publisher copy:
10.1083/jcb.200403084

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of cell biology
Volume:
166
Issue:
2
Pages:
167-172
Publication date:
2004-07-01
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Source identifiers:
196722

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