Journal article
Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila.
- Abstract:
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Centrosome defects are a common feature of many cancers, and they can predispose fly brain cells to form tumours. In flies, centrosome defects perturb the asymmetric division of the neural stem cells, but it is unclear how this might lead to malignant transformation. One possibility is that centrosome defects might also perturb cellular homeostasis: for example, stress pathways are often activated in response to centrosome defects in cultured cells, and stress contributes to tumourigenesis in...
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- Publisher copy:
- 10.1242/bio.20122238
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Bibliographic Details
- Journal:
- Biology open
- Volume:
- 1
- Issue:
- 10
- Pages:
- 983-993
- Publication date:
- 2012-10-01
- DOI:
- EISSN:
-
2046-6390
- Source identifiers:
-
365502
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:365502
- UUID:
-
uuid:c4319b2e-1c1b-42f5-a71f-4598cae97f6e
- Local pid:
- pubs:365502
- Deposit date:
- 2013-11-17
Terms of use
- Copyright date:
- 2012
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