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Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila.

Abstract:

Centrosome defects are a common feature of many cancers, and they can predispose fly brain cells to form tumours. In flies, centrosome defects perturb the asymmetric division of the neural stem cells, but it is unclear how this might lead to malignant transformation. One possibility is that centrosome defects might also perturb cellular homeostasis: for example, stress pathways are often activated in response to centrosome defects in cultured cells, and stress contributes to tumourigenesis in...

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Publisher copy:
10.1242/bio.20122238

Authors


Journal:
Biology open
Volume:
1
Issue:
10
Pages:
983-993
Publication date:
2012-10-01
DOI:
EISSN:
2046-6390
Source identifiers:
365502
Language:
English
Keywords:
Pubs id:
pubs:365502
UUID:
uuid:c4319b2e-1c1b-42f5-a71f-4598cae97f6e
Local pid:
pubs:365502
Deposit date:
2013-11-17

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