Journal article icon

Journal article

A highly active single-mutation variant of P450BM3 (CYP102A1).

Abstract:
The power of proline: Bold amino acid substitutions in sensitive protein regions are frequently unproductive, while more subtle mutations can be sufficient to bring about dramatic changes. But introducing proline at the residue next to the sulfur ligand in P450(BM3) (CYP102A1) has the unexpected and desirable effect of enhancing the activity of this fatty acid hydroxylase with a broad range of non-natural substrates, as illustrated by the figure.
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/cbic.200900279

Authors


Expand authors...
Journal:
Chembiochem : a European journal of chemical biology
Volume:
10
Issue:
10
Pages:
1654-1656
Publication date:
2009-07-05
DOI:
EISSN:
1439-7633
ISSN:
1439-4227
URN:
uuid:c4281306-67ed-47b0-a339-5554192abfbc
Source identifiers:
34741
Local pid:
pubs:34741

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP