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New crystal forms of Trypanosoma cruzi dUTPase.

Abstract:
The dUTPase from Trypanosoma cruzi has been crystallized in two crystal forms, both belonging to space group P6(3)22, with unit-cell parameters a = b = 134.67, c = 148.66 A (form I, two molecules per asymmetric unit) and a = b = 136.43, c = 68.71 A (form II, one molecule per asymmetric unit). Single-wavelength data have been collected using synchrotron radiation to 3.0 A for crystal form I and to 2.4 A for crystal form II and structure solution is under way. T. cruzi dUTPase is a potential target for anti-protozoan drug design.
Publication status:
Published

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Publisher copy:
10.1107/s0907444901004905

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Institution:
University of Oxford
Department:
Oxford, MSD, Structural Biology
Role:
Author
Journal:
Acta crystallographica. Section D, Biological crystallography
Volume:
57
Issue:
Pt 6
Pages:
915-917
Publication date:
2001-06-05
DOI:
EISSN:
1399-0047
ISSN:
0907-4449
URN:
uuid:c4230b91-6bda-4148-a815-de08a0beb983
Source identifiers:
31885
Local pid:
pubs:31885

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