Journal article icon

Journal article

Na(+)/H(+) exchange inhibition with HOE642 improves postischemic recovery due to attenuation of Ca(2+) overload and prolonged acidosis on reperfusion.

Abstract:

BACKGROUND: Na(+)/H(+) exchange inhibition with HOE642 (cariporide) improves postischemic recovery of cardiac function, but the mechanisms of action remain speculative. Because Na(+)/H(+) exchange is activated on reperfusion, it was hypothesized that its inhibition delays realkalinization and decreases intracellular Na(+) and, via Na(+)/Ca(2+) exchange, Ca(2+) overload. Attenuated Ca(2+) overload and prolonged acidosis are known to be cardioprotective. METHODS AND RESULTS:Left ventricular dev...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1161/01.cir.101.23.2749

Authors


Expand authors...
Journal:
Circulation
Volume:
101
Issue:
23
Pages:
2749-2755
Publication date:
2000-06-01
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Source identifiers:
124734

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP