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Na(+)/H(+) exchange inhibition with HOE642 improves postischemic recovery due to attenuation of Ca(2+) overload and prolonged acidosis on reperfusion.

Abstract:

BACKGROUND: Na(+)/H(+) exchange inhibition with HOE642 (cariporide) improves postischemic recovery of cardiac function, but the mechanisms of action remain speculative. Because Na(+)/H(+) exchange is activated on reperfusion, it was hypothesized that its inhibition delays realkalinization and decreases intracellular Na(+) and, via Na(+)/Ca(2+) exchange, Ca(2+) overload. Attenuated Ca(2+) overload and prolonged acidosis are known to be cardioprotective. METHODS AND RESULTS:Left ventricular dev...

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Publication status:
Published

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Publisher copy:
10.1161/01.cir.101.23.2749

Authors


Strömer, H More by this author
de Groot, MC More by this author
Leupold, A More by this author
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Journal:
Circulation
Volume:
101
Issue:
23
Pages:
2749-2755
Publication date:
2000-06-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:c422bce6-1eaf-4a76-8953-0b626911393d
Source identifiers:
124734
Local pid:
pubs:124734

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