The Impact of Different CD4 Cell-Count Monitoring and Switching Strategies on Mortality in HIV-Infected African Adults on Antiretroviral Therapy: An Application of Dynamic Marginal Structural Models.

Journal article

In Africa, antiretroviral therapy (ART) is delivered with limited laboratory monitoring, often none. In 2003-2004, investigators in the Development of Antiretroviral Therapy in Africa (DART) Trial randomized persons initiating ART in Uganda and Zimbabwe to either laboratory and clinical monitoring (LCM) or clinically driven monitoring (CDM). CD4 cell counts were measured every 12 weeks in both groups but were only returned to treating clinicians for management in the LCM group. Follow-up cont...

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Authors: Ford, D; Robins, J; Petersen, M; Gibb, D; Gilks, C

• Publication status: Published
• Journal: American journal of epidemiology
• Volume: 182
• Issue: 7
• Pages: 633-643
• Publication date: 2015-10-01
• DOI: 10.1093/aje/kwv083
• EISSN: 1476-6256
• ISSN: 0002-9262
• Language: English
• Keywords: DART Trial Team