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The Impact of Different CD4 Cell-Count Monitoring and Switching Strategies on Mortality in HIV-Infected African Adults on Antiretroviral Therapy: An Application of Dynamic Marginal Structural Models.

Abstract:

In Africa, antiretroviral therapy (ART) is delivered with limited laboratory monitoring, often none. In 2003-2004, investigators in the Development of Antiretroviral Therapy in Africa (DART) Trial randomized persons initiating ART in Uganda and Zimbabwe to either laboratory and clinical monitoring (LCM) or clinically driven monitoring (CDM). CD4 cell counts were measured every 12 weeks in both groups but were only returned to treating clinicians for management in the LCM group. Follow-up cont...

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Publication status:
Published

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Publisher copy:
10.1093/aje/kwv083

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Journal:
American journal of epidemiology
Volume:
182
Issue:
7
Pages:
633-643
Publication date:
2015-10-05
DOI:
EISSN:
1476-6256
ISSN:
0002-9262
URN:
uuid:c4207a0f-2d3d-41f7-8098-00a3d596b871
Source identifiers:
571356
Local pid:
pubs:571356
Language:
English
Keywords:

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