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Revealing compartmentalized diffusion in living cells with interferometric scattering microscopy

Abstract:

The spatiotemporal organization and dynamics of the plasma membrane and its constituents are central to cellular function. Fluorescence-based single-particle tracking has emerged as a powerful approach for studying the single molecule behavior of plasma-membrane-associated events because of its excellent background suppression, at the expense of imaging speed and observation time. Here, we show that interferometric scattering microscopy combined with 40 nm gold nanoparticle labeling can be us...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.bpj.2018.05.007

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Physical & Theoretical Chem
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Physical & Theoretical Chem
Oxford college:
Exeter College
Role:
Author
Publisher:
Cell Press Publisher's website
Journal:
Biophysical Journal Journal website
Volume:
114
Issue:
12
Pages:
2945-2950
Publication date:
2018-06-19
Acceptance date:
2018-05-02
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Pubs id:
pubs:856454
URN:
uri:c419bac7-9519-484d-8330-5fea7ce2659c
UUID:
uuid:c419bac7-9519-484d-8330-5fea7ce2659c
Local pid:
pubs:856454

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