Journal article
Adaptation to DNA damage as a bet-hedging mechanism in a fluctuating environment
- Abstract:
-
In response to DNA damage, efficient repair is essential for cell survival and genome integrity. In eukaryotes, the DNA damage checkpoint is a signalling pathway that coordinates this response and arrests the cell cycle to provide time for repair. However, when repair fails or when the damage is not repairable, cells can eventually bypass the DNA damage checkpoint and undergo cell division despite persistent damage, a process called adaptation to DNA damage. Interestingly, adaptation occurs w...
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- Publication status:
- Published
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Authors
Bibliographic Details
- Publisher:
- Royal Society Publisher's website
- Journal:
- Royal Society Open Science Journal website
- Volume:
- 8
- Issue:
- 8
- Article number:
- 210460
- Publication date:
- 2021-08-25
- Acceptance date:
- 2021-08-02
- DOI:
- EISSN:
-
2054-5703
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1226888
- Local pid:
- pubs:1226888
- Deposit date:
- 2022-01-02
Terms of use
- Copyright holder:
- Roux et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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