NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing.

Journal article

A cytotoxic T lymphocyte (CTL) kills an infected or tumorigenic cell by Ca(2+)-dependent exocytosis of cytolytic granules at the immunological synapse formed between the two cells. Although inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) release from the endoplasmic reticulum activates the store-operated Ca(2+)-influx pathway that is necessary for exocytosis, it is not a sufficient stimulus. Here we identify the Ca(2+)-mobilizing messenger nicotinic acid adenine dinucleotide phosphate (N...

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Authors: Davis, L; Morgan, A; Chen, J; Snead, C; Bloor-Young, D

• Publication status: Published
• Journal: Current biology : CB
• Volume: 22
• Issue: 24
• Pages: 2331-2337
• Publication date: 2012-12-01
• DOI: 10.1016/j.cub.2012.10.035
• EISSN: 1879-0445
• ISSN: 0960-9822
• Language: English
• Keywords: Exocytosis; Animals; Inositol 1,4,5-Trisphosphate; NADP; Humans; Cytoplasmic Granules; T-Lymphocytes, Cytotoxic; Lymphocyte Activation