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NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing.

Abstract:

A cytotoxic T lymphocyte (CTL) kills an infected or tumorigenic cell by Ca(2+)-dependent exocytosis of cytolytic granules at the immunological synapse formed between the two cells. Although inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) release from the endoplasmic reticulum activates the store-operated Ca(2+)-influx pathway that is necessary for exocytosis, it is not a sufficient stimulus. Here we identify the Ca(2+)-mobilizing messenger nicotinic acid adenine dinucleotide phosphate (N...

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Publication status:
Published

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Publisher copy:
10.1016/j.cub.2012.10.035

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Journal:
Current biology : CB
Volume:
22
Issue:
24
Pages:
2331-2337
Publication date:
2012-12-01
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
Source identifiers:
365478
Language:
English
Keywords:
Pubs id:
pubs:365478
UUID:
uuid:c40f2c20-d2b4-4004-a080-6c7c62a58382
Local pid:
pubs:365478
Deposit date:
2013-11-16

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