Journal article icon

Journal article

A SNP in the ACT gene associated with astrocytosis and rapid cognitive decline in AD.

Abstract:

There is biochemical and animal model evidence supporting a pathological role of the ACT gene in AD. However, direct genetic evidence remains controversial and has been mostly limited to individual single nucleotide polymorphism (SNP) analysis. To resolve this apparent conflict we have used a high-density ACT SNP map, constructed haplotypes and explored correlations with phenotype. SNPs were identified by sequencing and used to construct haplotypes in 668 AD patients and 419 controls and a ca...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Neurobiology of aging
Volume:
29
Issue:
8
Pages:
1167-1176
Publication date:
2008-08-01
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
Source identifiers:
195522
Language:
English
Keywords:
Pubs id:
pubs:195522
UUID:
uuid:c40cdbe7-7372-4f0e-a17f-74cf6b585a9b
Local pid:
pubs:195522
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP