A SNP in the ACT gene associated with astrocytosis and rapid cognitive decline in AD.

Journal article

There is biochemical and animal model evidence supporting a pathological role of the ACT gene in AD. However, direct genetic evidence remains controversial and has been mostly limited to individual single nucleotide polymorphism (SNP) analysis. To resolve this apparent conflict we have used a high-density ACT SNP map, constructed haplotypes and explored correlations with phenotype. SNPs were identified by sequencing and used to construct haplotypes in 668 AD patients and 419 controls and a ca...

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Authors: Belbin, O; Dunn, J; Chappell, S; Ritchie, A; Ling, Y

• Publication status: Published
• Journal: Neurobiology of aging
• Volume: 29
• Issue: 8
• Pages: 1167-1176
• Publication date: 2008-08-01
• DOI: 10.1016/j.neurobiolaging.2007.02.021
• EISSN: 1558-1497
• ISSN: 0197-4580
• Language: English
• Keywords: Humans; Genetic Predisposition to Disease; Female; LIM Domain Proteins; Male; Gliosis; Case-Control Studies; Polymorphism, Single Nucleotide; Cognition Disorders; Alzheimer Disease; Comorbidity; Great Britain; Aged; Incidence; Transcription Factors