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Radiosensitization by nitric oxide at low radiation doses.

Abstract:

Nitric oxide was shown to radiosensitize anoxic V79 and CHO hamster cells and MCF7 and UT-SCC-14 human cells, measuring clonogenic survival and/or DNA damage in vitro at low radiation doses (0.1-5 Gy). Radiosensitization was easily detected after 2 Gy in anoxic V79 cells exposed to 40 ppm ( approximately 70 nM) nitric oxide, indicating that nitric oxide is a significantly more efficient radiosensitizer than oxygen. The yield of double-strand breaks (as gamma-H2AX foci) in V79 and MCF7 cells w...

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Publication status:
Published

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Publisher copy:
10.1667/rr0827.1

Authors


Wardman, P More by this author
Rothkamm, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Woodcock, M More by this author
Johnston, PJ More by this author
Journal:
Radiation research
Volume:
167
Issue:
4
Pages:
475-484
Publication date:
2007-04-05
DOI:
EISSN:
1938-5404
ISSN:
0033-7587
URN:
uuid:c404641f-6dee-4e6d-9f85-72418c324d1e
Source identifiers:
261297
Local pid:
pubs:261297

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