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Elevated fasting plasma ghrelin in prader-willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance.

Abstract:

Plasma ghrelin is elevated in Prader-Willi syndrome (PWS). This might contribute to obesity or GH deficiency in such patients. Visceral adiposity and insulin resistance are reduced in PWS, which might lead to hyperghrelinemia. We measured fasting plasma ghrelin in control female (n = 39), PWS female (n = 12), and PWS male (n = 6) adults. In controls and PWS, ghrelin was negatively correlated with visceral adiposity, fasting insulin, and homeostasis model insulin resistance index. There was no...

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Publication status:
Published

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Publisher copy:
10.1210/jc.2003-031118

Authors


Goldstone, AP More by this author
Thomas, EL More by this author
Brynes, AE More by this author
Castroman, G More by this author
Edwards, R More by this author
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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
89
Issue:
4
Pages:
1718-1726
Publication date:
2004-04-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:c40411bb-28a8-42ee-ad5f-655ef61dfb7e
Source identifiers:
138238
Local pid:
pubs:138238

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