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Praziquantel pharmacokinetics and side effects in Schistosoma japonicum-infected patients with liver disease.

Abstract:

Praziquantel undergoes extensive first-pass hepatic biotransformation, but there is little information on its disposition or toxicity when administered to patients with liver disease. To define the influence of liver disease on the pharmacokinetics of praziquantel, we administered it orally to 30 patients with proven Schistosoma japonicum infection whose liver disease was carefully assessed as being severe, moderate, or absent. Both the peak plasma concentration of praziquantel and the bioava...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/157.3.530

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Fernando, MT More by this author
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Journal:
The Journal of infectious diseases
Volume:
157
Issue:
3
Pages:
530-535
Publication date:
1988-03-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:c4021e09-dca7-4410-aaa9-014a504608d9
Source identifiers:
42932
Local pid:
pubs:42932

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