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The MBP fusion protein restores the activity of the first phosphatase domain of CD45.

Abstract:

CD45 is a receptor-like protein tyrosine phosphatase critically involved in the regulation of initial effector functions in B- and T-cells. The protein comprises two phosphatase (PTP) domains in its cytoplasmic region. However, whether each PTP domain has enzyme activity by itself or whether both domains are required to build up a functional enzyme is unclear. We have studied different constructions of human CD45 comprising the two PTP domains, both separately and as a single protein, fused t...

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Publication status:
Published

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Authors


Lorenzo, HK More by this author
Germain, V More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Alzari, PM More by this author
Journal:
FEBS letters
Volume:
411
Issue:
2-3
Pages:
231-235
Publication date:
1997-07-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:c3fb5dfd-37dc-4383-8e9f-46fc51f5f7e7
Source identifiers:
24494
Local pid:
pubs:24494

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