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Journal article

A knowledge-driven approach for crystallographic protein model completion.

Abstract:

One of the most cumbersome and time-demanding tasks in completing a protein model is building short missing regions or ;loops'. A method is presented that uses structural and electron-density information to build the most likely conformations of such loops. Using the distribution of angles and dihedral angles in pentapeptides as the driving parameters, a set of possible conformations for the C(alpha) backbone of loops was generated. The most likely candidate is then selected in a hierarchical...

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Publication status:
Published

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Publisher copy:
10.1107/s0907444908001558

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Journal:
Acta crystallographica. Section D, Biological crystallography
Volume:
64
Issue:
Pt 4
Pages:
416-424
Publication date:
2008-04-05
DOI:
EISSN:
1399-0047
ISSN:
0907-4449
URN:
uuid:c3f90505-ff15-4423-bc61-8ec18b05c4e0
Source identifiers:
99770
Local pid:
pubs:99770

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