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A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart

Abstract:

Elevated levels of cardiac mitochondrial uncoupling protein 3 (UCP3) and decreased cardiac efficiency (hydraulic power/oxygen consumption) with abnormal cardiac function occur in obese, diabetic mice. To determine whether cardiac mitochondrial uncoupling occurs in non-genetic obesity, we fed rats a high fat diet (55% kcal from fat) or standard laboratory chow (7% kcal from fat) for 3 weeks, after which we measured cardiac function in vivo using cine MRI, efficiency in isolated working hearts ...

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Publisher copy:
10.1007/s00395-011-0156-1

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Journal:
Basic Research in Cardiology
Volume:
106
Issue:
3
Pages:
447-457
Publication date:
2011-05-01
DOI:
EISSN:
1435-1803
ISSN:
0300-8428
Source identifiers:
149794
Language:
English
Keywords:
Pubs id:
pubs:149794
UUID:
uuid:c3f59c8b-f06a-408e-94b0-c14e22c7b11d
Local pid:
pubs:149794
Deposit date:
2012-12-19

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