Pig pancreas oxygenation at 20 degrees C increases islet ATP generation but deteriorates islet function.

Journal article

Successful pancreas preservation during storage in oxygenated perfluorodecalin (PFD) is mainly related to oxidative ATP generation during storage. Increasing the storage temperature would accelerate this process essential for resuscitation of ischemically damaged pancreatic tissue. The present study aimed at comparing islet isolation outcome from adult pig pancreata preserved in oxygenated PFD by means of a one-layer method during storage on ice or at 20 degrees C. Resected pancreata were int...

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Authors: Iken, M; Brandhorst, H; Korsgren, O; Brandhorst, D

• Journal: Cell transplantation
• Volume: 18
• Issue: 7
• Pages: 745-751
• Publication date: 2009-01-01
• DOI: 10.3727/096368909x470838
• EISSN: 1555-3892
• ISSN: 0963-6897
• Language: English
• Keywords: Female; Mitochondria; Organ Preservation Solutions; Diabetes Mellitus; Organ Preservation; Temperature; Raffinose; Fluorocarbons; Mice; Oxygen; Islets of Langerhans; Swine; Adenosine; Mice, Nude; Adenosine Triphosphate; Cell Survival; Insulin; Animals; Allopurinol; Glutathione; Glucose; Islets of Langerhans Transplantation