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Journal article

Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks

Abstract:

Although we understand how serotonin receptors function at the single-cell level, what role different serotonin receptors play in regulating brain-wide activity and, in turn, human behavior, remains unknown. Here, we developed transcriptomic–neuroimaging mapping to characterize brain-wide functional signatures associated with specific serotonin receptors: serotonin receptor networks (SRNs). Probing SRNs with optogenetics–functional magnetic resonance imaging (MRI) and pharmacology in mice,...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41593-022-01213-3

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0003-3947-9541
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0002-5641-1306
More by this author
Role:
Author
ORCID:
0000-0002-4169-9781
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
110027/Z/15/Z
More from this funder
Name:
U.S. Department of Health & Human Services | National Institutes of Health (NIH)
Publisher:
Springer Nature
Journal:
Nature Neuroscience More from this journal
Volume:
26
Issue:
1
Pages:
53-63
Publication date:
2022-12-15
Acceptance date:
2022-10-24
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
Pmid:
36522497
Language:
English
Keywords:
Pubs id:
1315395
Local pid:
pubs:1315395
Deposit date:
2023-01-11

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