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General lessons from large-scale studies to identify human cancer predisposition genes.

Abstract:

There are now about 100 genes known to cause Mendelian inherited cancer syndromes, but these only explain a minor part of the familial clustering of the common cancers. The increased familial relative risk of cancer in the general population must largely involve genes of low- or moderate-penetrance. Until recently, attempts to identify cancer predisposition genes with low penetrance had proved similarly unrewarding. However, in the past 2 years, developments in this area have been rapid. In p...

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Publication status:
Published

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Publisher copy:
10.1002/path.2650

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
The Journal of pathology
Volume:
220
Issue:
2
Pages:
255-262
Publication date:
2010-01-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:c3b752fa-42ef-41ab-a07b-6d19f8ef58eb
Source identifiers:
138121
Local pid:
pubs:138121

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