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Journal article

The lymphocyte-specific protein tyrosine kinase p56lck is hyperphosphorylated on serine and tyrosine residues within minutes after activation via T cell receptor or CD2.

Abstract:

Human T cells can be activated and induced to proliferate through either the antigen-specific receptor complex (TcR-CD3) or the CD2 surface molecule. Following stimulation, both serine and tyrosine phosphorylation of cellular protein have been demonstrated to occur. p56lck, a protein tyrosine kinase associated to the inner face of the plasma membrane, is almost exclusively expressed in lymphoid cells, especially T cells. Within minutes after activation of a human T cell-derived line (Jurkat) ...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830191202

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
European journal of immunology
Volume:
19
Issue:
12
Pages:
2183-2189
Publication date:
1989-12-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:c3a538d2-1a87-48d3-bf04-f282569df28b
Source identifiers:
29415
Local pid:
pubs:29415

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